Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the blood. It works by blocking the enzyme that produces cholesterol in the liver [1]. The effectiveness of Lipitor may be affected by various factors, including high-fat foods.

According to a study published in the National Center for Biotechnology Information, the absorption of atorvastatin can be decreased when taken with a high-fat meal [2]. The study suggests that taking Lipitor with a high-fat meal may reduce its effectiveness in lowering cholesterol levels. However, the study also states that the clinical significance of this interaction may be minor, and that it may not be necessary to avoid high-fat meals while taking Lipitor.

Another study published in PubMed supports this claim, stating that while a high-fat meal may decrease the absorption of atorvastatin, it does not significantly affect its cholesterol-lowering effects [3]. The study concludes that patients taking Lipitor do not need to avoid high-fat meals, but may benefit from taking the medication at a different time than when they consume high-fat foods.

In summary, high-fat foods may decrease the absorption of Lipitor, but the clinical significance of this interaction is minor and may not significantly affect its cholesterol-lowering effects. Patients taking Lipitor do not need to avoid high-fat meals, but may benefit from taking the medication at a different time than when they consume high-fat foods [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312230/
[3] https://pubmed.ncbi.nlm.nih.gov/33804727/