Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood. According to the sources provided, taking Lipitor without meals can increase the risk of certain side effects.

The Cleveland Clinic [2] states that taking Lipitor with food can help reduce the risk of gastrointestinal side effects, such as stomach pain, nausea, and diarrhea. This is because taking the medication with food can slow down the absorption of the drug and reduce its impact on the stomach lining.

A study conducted by Lawson Health Research Institute [3] found that taking statins, including Lipitor, with food can also reduce the risk of liver damage. The study showed that patients who took statins with food had lower levels of liver enzymes, which can be a sign of liver damage.

Additionally, the Drug Patent Watch [1] states that taking Lipitor without meals can reduce the effectiveness of the medication. This is because the medication is absorbed differently when taken with or without food, and taking it without food may result in lower levels of the drug in the bloodstream.

In conclusion, taking Lipitor without meals can increase the risk of gastrointestinal side effects and reduce the effectiveness of the medication. It is recommended to take Lipitor with food to reduce the risk of side effects and improve its efficacy. However, patients should always consult with their healthcare provider before making any changes to their medication regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://my.clevelandclinic.org/health/treatments/22282-statins
[3] https://www.lawsonresearch.ca/news/taking-cholesterol-medication-food-could-reduce-risk-side-effects