Acetaminophen is a commonly used pain reliever that is generally safe when taken as directed. However, when taken in combination with other medications, including Lipitor, it can lead to potential side effects.

According to the drug interaction checker on drugs.com [2], there are no known interactions between acetaminophen and Lipitor. However, the National Institutes of Health [3] notes that acetaminophen can interact with other medications that are metabolized by the liver, which is also where Lipitor is metabolized. This can potentially increase the risk of liver damage.

Additionally, both acetaminophen and Lipitor can cause liver damage on their own. Acetaminophen can cause liver damage when taken in high doses or when combined with alcohol [1]. Lipitor can also cause liver damage, although this is rare [3].

Other potential side effects of acetaminophen include allergic reactions, skin rash, and gastrointestinal upset [1]. Lipitor can cause muscle pain, weakness, and liver problems, among other side effects [3].

In summary, while there are no known interactions between acetaminophen and Lipitor, both medications can potentially cause liver damage on their own. Patients should be cautious when taking these medications together and should consult with their healthcare provider if they experience any concerning symptoms.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ACETAMINOPHEN
[2] https://www.drugs.com/drug-interactions/acetaminophen-with-lipitor-11-0-276-128.html
[3] https://www.ncbi.nlm.nih.gov/books/NBK548162/