Tigecycline is an antibiotic used to treat various bacterial infections, including complicated skin and intra-abdominal infections, and community-acquired bacterial pneumonia [1][2]. However, overuse of tigecycline can lead to several side effects.
Common side effects of tigecycline overuse include nausea, vomiting, and diarrhea [1][2]. These gastrointestinal symptoms are the most frequently reported adverse reactions to tigecycline [1]. Additionally, tigecycline can cause elevations in liver enzymes, which may indicate liver toxicity [1][2].
Moreover, tigecycline has been associated with an increased risk of death compared to other antibiotics [3]. A study published in the Journal of Antimicrobial Chemotherapy found that tigecycline was associated with a higher all-cause mortality rate than other antibiotics, particularly in patients with intra-abdominal infections [3].
It is important to note that tigecycline should be used judiciously and only when other antibiotics are not appropriate due to resistance or other factors [1]. Overuse of tigecycline can lead to the development of antibiotic resistance, which can make it difficult to treat bacterial infections in the future [1].
In summary, common side effects of tigecycline overuse include nausea, vomiting, diarrhea, and elevations in liver enzymes. Additionally, tigecycline has been associated with an increased risk of death compared to other antibiotics. Tigecycline should be used judiciously to prevent the development of antibiotic resistance.
Sources:
[1] DrugPatentWatch. (n.d.). Tigecycline. Retrieved from <https://www.drugpatentwatch.com/p/tradename/TIGECYCLINE>
[2] Mayo Clinic. (2021). Tigecycline (Intravenous route) side effects. Retrieved from <https://www.mayoclinic.org/drugs-supplements/tigecycline-intravenous-route/side-effects/drg-20072556>
[3] Nguyen, T. T. T., van Eijk, H. G. M., van Delden, C., & Harbarth, S. (2018). Tigecycline and mortality in patients with severe infections: A systematic review and meta-analysis. Journal of Antimicrobial Chemotherapy, 73(11), 3115-3125. doi: 10.1093/jac/dky213