Lipitor, also known as atorvastatin, is a medication used to lower cholesterol levels in the body [1]. The medication works by blocking an enzyme that produces cholesterol in the liver. Herbal supplements are commonly used for various health benefits, but they may interact with prescription medications, including Lipitor.

According to the Mayo Clinic, some herbal supplements may interact with Lipitor and increase the risk of side effects. For example, St. John's wort, which is used for depression, anxiety, and sleep disorders, may decrease the effectiveness of Lipitor and increase the risk of muscle pain and liver damage [2]. Additionally, garlic supplements, which are used to lower cholesterol levels, may increase the risk of bleeding when taken with Lipitor [2].

The National Health Service (NHS) also warns that grapefruit juice may interact with Lipitor and increase the risk of side effects. Grapefruit juice contains a compound that can increase the amount of Lipitor in the bloodstream, leading to an increased risk of muscle pain and liver damage [3]. Therefore, it is recommended to avoid grapefruit juice while taking Lipitor.

In conclusion, Lipitor may interact with certain herbal supplements, including St. John's wort, garlic supplements, and grapefruit juice. It is essential to talk to a healthcare provider before taking any herbal supplements while on Lipitor to avoid potential side effects and interactions [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.mayoclinic.org/healthy-lifestyle/consumer-health/in-depth/herbal-supplements/art-20046488
[3] https://www.nhs.uk/medicines/atorvastatin/taking-atorvastatin-with-other-medicines-and-herbal-supplements/