Lipitor is a prescription drug used to lower cholesterol levels in the blood. Grapefruit juice contains compounds that can interfere with the metabolism of some drugs, including Lipitor. This can increase the concentration of the drug in the bloodstream and lead to potential side effects. Therefore, it is generally not recommended to mix Lipitor and grapefruit juice.

According to Drug Patent Watch [1], Lipitor's active ingredient, atorvastatin, is metabolized by the liver's CYP3A4 enzyme. Grapefruit juice contains compounds that inhibit this enzyme, leading to an increase in the concentration of atorvastatin in the bloodstream. This can increase the risk of side effects such as muscle pain, liver damage, and kidney failure.

Ro [2] suggests that the effects of grapefruit juice on Lipitor can last for up to 72 hours after consumption. Therefore, it is recommended to avoid grapefruit juice while taking Lipitor.

Verywell Health [3] also warns against mixing Lipitor and grapefruit juice. They suggest that patients should talk to their doctor or pharmacist about any potential interactions between Lipitor and other medications or supplements they are taking.

In conclusion, based on the sources provided, it is not safe to mix Lipitor and grapefruit juice. Patients should avoid consuming grapefruit juice while taking Lipitor and should talk to their doctor or pharmacist about any potential interactions with other medications or supplements they are taking.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://ro.co/health-guide/lipitor-and-grapefruit/
[3] https://www.verywellhealth.com/can-i-take-lipitor-or-zocor-with-grapefruit-juice-1124045