Lipitor (atorvastatin) is a medication used to lower cholesterol levels, while ACE inhibitors are a class of drugs used to treat high blood pressure. According to a study published in the International Journal of Cardiology [2], taking Lipitor and ACE inhibitors together is generally safe and can be beneficial for patients with both high cholesterol and high blood pressure. However, as with any medication, there may be potential interactions and side effects to consider.

The study found that combining atorvastatin with ACE inhibitors did not significantly affect blood pressure or heart rate in patients with hypertension. Additionally, the combination therapy was found to have a synergistic effect on reducing inflammation, which is a risk factor for cardiovascular disease. However, the study also noted that there may be a risk of developing muscle-related side effects, such as myopathy or rhabdomyolysis, when taking atorvastatin and ACE inhibitors together. Therefore, it is important to monitor patients closely for any signs of muscle pain or weakness.

The Mayo Clinic [3] also notes that combining atorvastatin with ACE inhibitors can increase the risk of developing hyperkalemia, a condition characterized by high levels of potassium in the blood. Patients should be monitored for any signs of hyperkalemia, such as muscle weakness or irregular heartbeat.

In conclusion, taking Lipitor and ACE inhibitors together can be safe and beneficial for patients with high cholesterol and high blood pressure. However, patients should be closely monitored for potential interactions and side effects, particularly related to muscle pain or weakness and hyperkalemia.

Sources:
[2] https://pubmed.ncbi.nlm.nih.gov/27590905/
[3] https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/ace-inhibitors/art-20047480