Lipitor is a brand name for atorvastatin, which is a medication used to lower cholesterol levels in the blood. St. John's Wort is an herbal supplement that is commonly used to treat depression, anxiety, and sleep disorders.

According to a study published in the Journal of Clinical Pharmacology [2], St. John's Wort can interact with several medications, including Lipitor. The study found that St. John's Wort can decrease the effectiveness of Lipitor by increasing its metabolism and reducing its absorption. This interaction can lead to a decrease in the therapeutic effect of Lipitor, which can result in increased cholesterol levels and a higher risk of heart disease.

It is important to note that the interaction between Lipitor and St. John's Wort is not well-established, and more research is needed to fully understand the extent of the interaction. However, it is recommended that patients taking Lipitor should avoid taking St. John's Wort or any other herbal supplements without consulting their healthcare provider [3].

In conclusion, Lipitor may interact with St. John's Wort, which can decrease the effectiveness of the medication. Patients taking Lipitor should avoid taking St. John's Wort or any other herbal supplements without consulting their healthcare provider.

Sources:
[2] https://pubmed.ncbi.nlm.nih.gov/17701167/
[3] https://www.herbalgram.org/resources/herbclip/issues/bin_339/review45121/
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR