There is no definitive evidence or scientific studies available that directly link Sapropterin use to memory recall over time. Sapropterin, a drug used to reduce symptoms in patients with phenylketonuria (PKU), has been studied primarily for its effects on PKU management and not on cognitive functions such as memory recall [1].

It is important to note that drugs can have various side effects, and patients should always consult with their healthcare providers regarding any concerns or observed changes in cognitive functions while taking any medication, including Sapropterin. Furthermore, clinical trials and post-market surveillance are ongoing processes, and new information may become available in the future [2][3].

In summary, based on the available information, there is currently no evidence to suggest that Sapropterin use directly affects memory recall over time.

Sources:
[1] DrugPatentWatch.com. (n.d.). Sapropterin. Retrieved from https://www.drugpatentwatch.com/drugs/sapropterin
[2] National Institutes of Health. (2021, April 21). Phenylketonuria. Genetics Home Reference. Retrieved from https://medlineplus.gov/genetics/condition/phenylketonuria/
[3] U.S. National Library of Medicine. (2021, March 17). Sapropterin. DailyMed. Retrieved from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=268d6e2c-9d2e-4e3e-a7d7-67b269b1b2b2&type=display