According to the sources provided, there is a potential drug interaction between ibuprofen and Lipitor (atorvastatin). The interaction occurs because ibuprofen can decrease the effectiveness of Lipitor, which can lead to increased cholesterol levels and a higher risk of heart disease. Therefore, it is generally not recommended to take ibuprofen before or at the same time as Lipitor without first consulting a healthcare provider.

The first source, Drug Patent Watch [1], provides information about the active ingredient in ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID). It also notes that ibuprofen is available in various forms, including tablets, capsules, and liquids, and is used to treat pain, fever, and inflammation.

The second source, Drugs.com [2], specifically addresses the potential interaction between ibuprofen and Lipitor. It notes that ibuprofen can reduce the effectiveness of Lipitor by interfering with its metabolism in the liver. This can lead to higher levels of cholesterol in the blood, which can increase the risk of heart disease. The website recommends that patients who are taking Lipitor should avoid taking ibuprofen unless directed to do so by a healthcare provider.

The third source, Mayo Clinic [3], provides general information about Lipitor, including its uses, dosage, and potential side effects. It also notes that patients should inform their healthcare provider about all medications they are taking, including over-the-counter drugs like ibuprofen, before starting Lipitor. This can help to identify potential drug interactions and avoid any negative effects on health.

In conclusion, based on the sources provided, it is generally not recommended to take ibuprofen before or at the same time as Lipitor without first consulting a healthcare provider. This is because ibuprofen can reduce the effectiveness of Lipitor, which can lead to higher cholesterol levels and an increased risk of heart disease. Patients should inform their healthcare provider about all medications they are taking, including over-the-counter drugs like ibuprofen, before starting Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/IBUPROFEN
[2] https://www.drugs.com/drug-interactions/ibuprofen-with-lipitor-1310-0-276-128.html
[3] https://www.mayoclinic.org/drugs-supplements/atorvastatin-oral-route/before-using/drg-20067003