Lipitor is a medication used to treat high cholesterol, and it belongs to a class of drugs called statins. Grapefruit juice contains compounds that can interfere with the way the body metabolizes certain medications, including Lipitor. The juice can increase the level of the drug in the bloodstream, which can lead to potentially dangerous side effects. According to Drug Patent Watch [1], Lipitor's patent expired in 2011, and it is now available as a generic medication.

The active ingredient in Lipitor is atorvastatin, and it is metabolized by an enzyme in the liver called CYP3A4. Grapefruit juice contains compounds called furanocoumarins, which inhibit this enzyme's activity, leading to higher levels of the drug in the bloodstream [2]. This can increase the risk of side effects such as muscle pain, liver damage, and kidney failure [3].

It is recommended to avoid consuming grapefruit or grapefruit juice while taking Lipitor or other statins. If you are taking Lipitor, it is essential to talk to your doctor or pharmacist about any other medications or supplements you are taking, as they may also interact with the drug [2]. It is also important to note that the interaction between grapefruit juice and Lipitor is not unique to this medication and can occur with other drugs metabolized by CYP3A4 [3].

In conclusion, grapefruit juice should be avoided while taking Lipitor due to the potential for dangerous side effects. Patients should always consult with their healthcare provider before taking any new medications or supplements and should inform them of any existing medical conditions or medications they are currently taking [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.verywellhealth.com/can-i-take-lipitor-or-zocor-with-grapefruit-juice-1124045
[3] https://www.health.harvard.edu/heart-health/grapefruit-juice-and-statins