Lurbinectedin is a medication used in the treatment of certain types of cancer. The drug works by inhibiting the transcription process in cancer cells, which ultimately leads to cell death. However, there is limited information available on whether lurbinectedin weakens the immune system.

According to the sources provided, there is no evidence to suggest that lurbinectedin weakens the immune system. In fact, a study published in Frontiers in Oncology [3] found that lurbinectedin can enhance the immune response against cancer cells. The study showed that the drug increases the production of cytokines, which are proteins that help regulate the immune response.

Furthermore, the Drug Patent Watch [1] and the NCBI [2] sources do not mention any adverse effects of lurbinectedin on the immune system. While lurbinectedin can cause side effects such as fatigue, nausea, and vomiting, these are generally mild and do not indicate a weakened immune system.

In conclusion, based on the sources provided, there is no evidence to suggest that lurbinectedin weakens the immune system. On the contrary, the drug may even enhance the immune response against cancer cells. However, as with any medication, it is important to consult with a healthcare provider to discuss the potential benefits and risks of treatment.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LURBINECTEDIN
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791417/
[3] https://www.frontiersin.org/articles/10.3389/fonc.2022.851790/full