Keytruda, also known as pembrolizumab, is an immunotherapy drug that has been approved by the FDA for the treatment of several types of cancer, including melanoma, lung cancer, and head and neck cancer. The drug works by blocking a protein called PD-1, which helps cancer cells evade the immune system. By blocking PD-1, Keytruda helps the immune system recognize and attack cancer cells [1].
According to a recent study, patients with advanced melanoma who received Keytruda had a five-year survival rate of 34%, which is significantly higher than the survival rate of patients who received other treatments [2]. This suggests that Keytruda can have long-term benefits for patients with advanced melanoma.
However, like all drugs, Keytruda can have side effects. Some of the most common side effects of Keytruda include fatigue, nausea, diarrhea, and skin rash. In rare cases, Keytruda can cause serious side effects, such as inflammation of the lungs, liver, or kidneys [3].
A recent study also found that some patients who received immune checkpoint inhibitors like Keytruda for melanoma experienced long-term side effects, including thyroid dysfunction, pituitary gland dysfunction, and diabetes. These side effects can occur months or even years after treatment and can have a significant impact on a patient's quality of life [2].
In conclusion, Keytruda has been shown to have long-term benefits for patients with advanced melanoma, with a higher survival rate compared to other treatments. However, like all drugs, Keytruda can have side effects, including rare but serious side effects that can occur months or years after treatment. Patients should discuss the potential benefits and risks of Keytruda with their healthcare provider before starting treatment [1][2][3].
Sources:
[1] https://www.drugpatentwatch.com/p/biologics/tradename/KEYTRUDA
[2] https://www.cancer.gov/news-events/cancer-currents-blog/2021/immune-checkpoint-inhibitors-melanoma-long-term-side-effects
[3] https://www.goodrx.com/pembrolizumab/long-term-effects-of-keytruda