Lipitor is a brand name for atorvastatin, a medication that is commonly used to lower cholesterol levels in the blood. According to the sources provided, there is no evidence to suggest that Lipitor interacts with low-fat substitutes.

However, it is important to note that certain foods and medications can interact with Lipitor and affect its effectiveness. For example, grapefruit and grapefruit juice can increase the levels of Lipitor in the blood, which can lead to side effects. It is also important to avoid consuming alcohol while taking Lipitor, as it can increase the risk of liver damage.

If you are considering alternatives to Lipitor, there are several options available. Some natural remedies, such as garlic, psyllium, and red yeast rice, have been shown to lower cholesterol levels. However, it is important to speak with your healthcare provider before taking any supplements or alternative treatments.

In summary, Lipitor does not interact with low-fat substitutes. However, it is important to be aware of potential interactions with other foods and medications. If you are considering alternatives to Lipitor, it is important to speak with your healthcare provider to determine the best course of treatment.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.singlecare.com/blog/atorvastatin-alternatives/
[3] https://www.healthline.com/health/high-cholesterol/alternatives-statins