Interactions between antidepressants and Advil (ibuprofen) can potentially worsen antidepressant side effects. It is crucial to consult a healthcare professional or pharmacist before combining any medications, including antidepressants and over-the-counter drugs like Advil. According to DrugPatentWatch.com [1], the following types of interactions may occur:

1. Increased Risk of Bleeding: Both antidepressants and Advil can increase the risk of bleeding, especially when taken together. Selective serotonin reuptake inhibitors (SSRIs) and nonsteroidal anti-inflammatory drugs (NSAIDs) like Advil can thin the blood and lead to stomach ulcers, gastrointestinal bleeding, or even brain hemorrhage [1][2].

2. Serotonin Syndrome: Combining antidepressants, particularly monoamine oxidase inhibitors (MAOIs) or SSRIs, with Advil can result in serotonin syndrome. This condition occurs when there is an excess of serotonin in the body, causing symptoms such as agitation, confusion, rapid heart rate, high blood pressure, dilated pupils, loss of muscle coordination, muscle rigidity, diarrhea, shivering, sweating, and fever [1][3].

3. Reduced Antidepressant Effectiveness: Concurrent use of antidepressants and Advil may decrease the effectiveness of antidepressants. NSAIDs like Advil can interfere with the cyclooxygenase (COX) enzymes, which play a role in the mechanism of action of some antidepressants [1][4].

4. Kidney Damage: Long-term use of NSAIDs like Advil can cause kidney damage or impair kidney function. Antidepressants, particularly SSRIs, can also affect kidney function. Combining these medications may increase the risk of kidney damage [1][5].

Sources:

1. DrugPatentWatch.com. (n.d.). Antidepressants - Drug Interactions. Retrieved from https://www.drugpatentwatch.com/drug-interactions/antidepressants
2. National Institute of Diabetes and Digestive and Kidney Diseases. (2016, September). NSAIDs: Understanding Side Effects and Risks. Retrieved from https://www.niddk.nih.gov/health-information/illnesses-conditions/nsaids-understanding-side-effects-risks
3. National Institute of Mental Health. (2018, January). Suicide Prevention. Retrieved from https://www.nimh.nih.gov/health/topics/suicide-prevention/index.shtml
4. National Alliance on Mental Illness. (2019, June). Antidepressants. Retrieved from https://www.nami.org/Learn-More/Treatment/Mental-Health-Medications/Antidepressants
5. Mayo Clinic. (2020, September 11). Kidney Problems. Retrieved from https://www.mayoclinic.org/diseases-conditions/kidney-problems/symptoms-causes/syc-20354521