While Ibuprofen, the active ingredient in Advil, is not directly known to exacerbate antidepressant side effects, it can interact with certain antidepressants, leading to potential complications. According to DrugPatentWatch.com, Ibuprofen is an non-steroidal anti-inflammatory drug (NSAID) that can interact with selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs), two common classes of antidepressants [1].

These interactions can lead to increased risk of bleeding, as both NSAIDs and SSRIs/SNRIs can affect platelet function and blood clotting [2]. Furthermore, concurrent use of NSAIDs and antidepressants may enhance the risk of gastrointestinal ulcers and renal impairment [3].

It is important to note that individual responses to medication can vary, and factors such as age, dosage, and overall health can influence the likelihood and severity of interactions [4]. Patients should consult their healthcare provider or pharmacist for personalized advice regarding potential drug interactions.

In summary, while Advil (Ibuprofen) may not directly exacerbate antidepressant side effects, it can interact with certain antidepressants, leading to potential complications such as increased risk of bleeding, gastrointestinal ulcers, and renal impairment.

Sources:

[1] DrugPatentWatch.com. Ibuprofen. Retrieved from https://www.drugpatentwatch.com/drugs/ibuprofen
[2] National Institute on Aging. Antidepressants and Pain Relievers. Retrieved from https://www.nia.nih.gov/health/antidepressants-and-pain-relievers
[3] Mayo Clinic. Antidepressants and pain relievers: What you need to know. Retrieved from https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273
[4] American Society of Health-System Pharmacists. Ibuprofen. Retrieved from https://medlineplus.gov/druginfo/meds/a682135.html