Lipitor (atorvastatin) is a medication used to lower cholesterol levels in the blood, while opioids are a class of drugs used to treat pain. The interaction between Lipitor and opioids is a concern due to the potential for adverse effects when used together.

According to Drug Patent Watch [1], there are no known drug interactions between Lipitor and opioids. However, caution should still be exercised when taking these medications together. Lipitor can cause muscle pain and weakness, and opioids can also cause muscle weakness and respiratory depression. When used together, these effects may be intensified, leading to serious complications.

A study published in the Journal of Pain Research [2] suggests that opioids can interfere with the effectiveness of statins, including Lipitor. The study found that patients taking opioids had lower levels of high-density lipoprotein (HDL) cholesterol, also known as "good" cholesterol, compared to those not taking opioids. This suggests that opioids may interfere with the ability of statins to lower cholesterol levels.

Drugs.com [3] lists several potential drug interactions between Lipitor and opioids, including an increased risk of muscle pain, weakness, and kidney damage. It is important to talk to your doctor if you are taking both Lipitor and opioids to monitor for potential adverse effects.

In conclusion, while there are no known drug interactions between Lipitor and opioids, caution should still be exercised when taking these medications together. Opioids may interfere with the effectiveness of Lipitor, and there is a potential for serious complications, including muscle pain, weakness, and respiratory depression. It is important to talk to your doctor if you are taking both medications to monitor for potential adverse effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351822/
[3] https://www.drugs.com/drug-interactions/lipitor-with-oxycodone-276-128-1770-0.html