Based on the provided sources, it is possible for Lipitor (atorvastatin) and selective serotonin reuptake inhibitors (SSRIs) to interact negatively.

Lipitor is a medication commonly prescribed to lower cholesterol levels and reduce the risk of cardiovascular events [1]. On the other hand, SSRIs are a class of antidepressant drugs used to treat various mental health conditions [3].

The first source, Drug Patent Watch, provides information on the drug Lipitor, but it does not specifically mention any interactions between Lipitor and SSRIs [1]. Therefore, it does not directly contribute to answering the question.

However, the second source, a study published in the Journal of Clinical Psychiatry, discusses potential drug interactions involving SSRIs [3]. It highlights that SSRIs can inhibit certain enzymes in the liver, such as CYP2D6, which are responsible for metabolizing various drugs, including Lipitor. This inhibition can lead to higher levels of Lipitor in the bloodstream, potentially increasing the risk of adverse effects [3].

Additionally, the third source, a study published in the National Center for Biotechnology Information (NCBI), further supports the potential interaction between SSRIs and Lipitor [2]. It states that certain SSRIs, like fluoxetine and paroxetine, can inhibit CYP3A4, another enzyme involved in the metabolism of Lipitor. This inhibition can also result in increased levels of Lipitor, potentially leading to unwanted side effects [2].

It is important to note that not all SSRIs have the same inhibitory effect on these enzymes, and the severity of the interaction may vary depending on the specific SSRI and individual patient factors. Therefore, it is crucial to consult with a healthcare professional, such as a doctor or pharmacist, who can assess the individual's specific situation and provide personalized advice.

In conclusion, based on the provided sources, there is evidence to suggest that certain SSRIs can potentially interact negatively with Lipitor. These interactions may result in increased levels of Lipitor in the bloodstream, which can lead to an increased risk of adverse effects. It is advisable to consult with a healthcare professional for personalized advice regarding the concomitant use of Lipitor and SSRIs.

Sources:
[1] Drug Patent Watch. Lipitor - Tradename Details. Retrieved from https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] National Center for Biotechnology Information (NCBI). Drug Interactions between Atorvastatin and Selective Serotonin Reuptake Inhibitors. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/
[3] The Journal of Clinical Psychiatry. Selective Serotonin Reuptake Inhibitor Drug Interactions: An Update. Retrieved from https://www.psychiatrist.com/jcp/selective-serotonin-reuptake-inhibitor-drug-interactions/