Advil is a brand name for the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen. Ibuprofen is used to relieve pain, reduce fever, and decrease inflammation. Advil works by inhibiting the production of prostaglandins, which are chemicals that cause inflammation, pain, and fever in the body [1].

However, NSAIDs like Advil can have adverse effects on the stomach lining. NSAIDs block the production of prostaglandins, which also protect the stomach lining by reducing the production of stomach acid and increasing the production of mucus that coats the stomach lining. When the production of prostaglandins is inhibited, the stomach lining becomes more vulnerable to damage from stomach acid, leading to stomach ulcers and bleeding [2].

To reduce the risk of stomach problems when taking Advil, it is recommended to take it with food or milk to help protect the stomach lining [3]. Additionally, it is important to follow the recommended dosage and not exceed the maximum daily dose of 1200 mg for adults [1].

In conclusion, Advil works by inhibiting the production of prostaglandins, which can lead to adverse effects on the stomach lining. To reduce the risk of stomach problems, it is recommended to take Advil with food or milk and to follow the recommended dosage [1-3].

Sources:
[1] Drug Patent Watch. (n.d.). Advil. Retrieved September 22, 2021, from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] Hospital for Special Surgery. (n.d.). Guidelines to Reduce the Side Effects of NSAIDs. Retrieved September 22, 2021, from https://www.hss.edu/conditions_guidelines-reduce-side-effects-nsaids.asp
[3] Healthline. (2021, August 18). Should You Take Ibuprofen on an Empty Stomach? Retrieved September 22, 2021, from https://www.healthline.com/health/ibuprofen-on-empty-stomach