Avocado is a nutritious fruit that is known for its heart-healthy benefits. However, if you are taking Lipitor, a cholesterol-lowering medication, you may wonder if avocado can interfere with its absorption.

According to the Drug Patent Watch [1], Lipitor's active ingredient is atorvastatin calcium, which is absorbed in the small intestine. Lipitor is not known to interact with avocado or any other food, but it is recommended to take it with a glass of water at the same time every day.

The AARP [2] notes that grapefruit and grapefruit juice are the only known foods that can interfere with Lipitor's metabolism. Grapefruit contains compounds that inhibit the enzymes responsible for breaking down Lipitor in the liver, which can increase the medication's concentration in the bloodstream and cause side effects. However, avocado does not contain these compounds and is not expected to affect Lipitor's absorption or metabolism.

In fact, Healthline [3] reports that avocado may have a positive impact on cholesterol levels and may even enhance the lipid-lowering effects of statins like Lipitor. Avocado is rich in monounsaturated fats, fiber, and plant sterols, which can help reduce LDL ("bad") cholesterol and increase HDL ("good") cholesterol. Therefore, incorporating avocado into a heart-healthy diet may be beneficial for individuals with high cholesterol, including those taking Lipitor.

In conclusion, there is no evidence to suggest that avocado can interfere with Lipitor absorption. In fact, avocado may even complement the lipid-lowering effects of the medication. However, it is always recommended to consult with a healthcare provider before making any significant changes to your diet or medication regimen.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.aarp.org/health/drugs-supplements/info-2022/food-medication-interaction.html
[3] https://www.healthline.com/health/high-cholesterol/avocado-and-cholesterol