There is no definitive scientific evidence to suggest that taking Advil (ibuprofen) will worsen sleep problems caused by Wellbutrin (bupropion). However, it is important to note that both medications can have side effects that may impact sleep.

Wellbutrin is an antidepressant that can cause insomnia or other sleep disturbances as a side effect [1]. On the other hand, Advil is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain, fever, and inflammation. While drowsiness is not a common side effect of Advil, it is possible that taking it close to bedtime could potentially disrupt sleep [2].

It is always recommended to consult with a healthcare provider or pharmacist if you have concerns about potential drug interactions or side effects. They can provide personalized advice based on your medical history and current medications.

In summary, while there is no direct evidence that Advil can worsen sleep problems caused by Wellbutrin, both medications can have side effects that impact sleep. It is always best to consult with a healthcare provider for personalized advice.

Sources:
[1] "Wellbutrin (bupropion): Side Effects, Dosages, Treatment, Interactions, Warnings." RxList, www.rxlist.com/wellbutrin-drug.htm.
[2] "Ibuprofen (Advil): Side Effects, Dosage, Uses, and More." Healthline, Healthline Media, 15 Sept. 2020, www.healthline.com/health/ibuprofen-oral.
[3] "Advil (Ibuprofen) Drug Interactions." Drugs.com, Drugs.com, www.drugs.com/drug-interactions/advil-ibuprofen.html.
[4] "Wellbutrin and Advil Interaction." Drugs.com, Drugs.com, www.drugs.com/drug-interactions/wellbutrin-and-advil-ibuprofen-103-1179-112-112.html.
[5] "Ibuprofen." DrugPatentWatch, drugpatentwatch.com/drugs/ibuprofen.