Yes, mutations in beta sheets can cause changes in protein-protein interactions. Beta sheets are a type of secondary structure in proteins, consisting of extended chains of amino acids held together by hydrogen bonds. These sheets play a crucial role in the formation of the three-dimensional structure of proteins, which in turn determines their function.

Mutations in the beta sheet regions of a protein can disrupt the hydrogen bonds and alter the overall structure of the protein. This can lead to changes in the protein's ability to interact with other proteins, as these interactions are often mediated by specific structural features. Such changes can have significant consequences for the protein's function and, by extension, the overall health of the organism.

For instance, mutations in beta sheets have been implicated in a number of diseases, including certain forms of cancer and neurodegenerative disorders. These mutations can alter the protein's normal function, leading to the accumulation of misfolded proteins and the formation of aggregates, which can be toxic to cells.

In the context of drug development, understanding the role of beta sheets in protein-protein interactions is crucial. Drugs that target these interactions can be used to modulate protein function and treat diseases caused by protein misfolding or aggregation. For example, drugs that stabilize beta sheets or prevent their aggregation can be used to treat neurodegenerative disorders such as Alzheimer's and Parkinson's diseases.

In summary, mutations in beta sheets can cause changes in protein-protein interactions, with significant implications for protein function and disease. Understanding these interactions is crucial for the development of drugs that target protein misfolding and aggregation.

Sources:

1. [DrugPatentWatch.com](https://www.drugpatentwatch.com/understanding-protein-protein-interactions-implications-for-drug-discovery/)
2. Nelson, D. L., & Cox, M. M. (2013). Lehninger Principles of Biochemistry. New York: W.H. Freeman.
3. Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., & Walter, P. (2002). Molecular Biology of the Cell. New York: Garland Science.