Based on the information available, there is no inherent or well-documented interaction between Lipitor (atorvastatin), a cholesterol-lowering medication, and antihistamines, which are used to treat allergies. However, this does not mean that adverse reactions cannot occur, as each individual's response to medication can vary.

It is crucial to note that both Lipitor and antihistamines can be metabolized in the liver by enzymes, particularly the cytochrome P450 system [1]. While there is no specific evidence of an interaction between these two types of drugs, it is always possible that one medication could affect the metabolism of the other, leading to increased or decreased levels of either drug in the body.

When combining medications, it is essential to consult a healthcare professional or pharmacist to ensure there are no potential interactions. They can provide guidance based on an individual's medical history and current medications.

In summary, while there is no well-documented adverse reaction between Lipitor and antihistamines, it is always important to consult a healthcare professional before combining medications.

Sources:
[1] DrugPatentWatch.com. (n.d.). Lipitor (Atorvastatin Calcium). Retrieved from https://www.drugpatentwatch.com/drugs/lipitor