Yes, aspirin can cause stomach issues unlike some newer medications. Aspirin is a type of nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation in the body. However, this inhibition can also lead to the production of more stomach acid, which can cause stomach irritation, ulcers, and other gastrointestinal problems [3].

Newer NSAIDs, such as celecoxib (Celebrex), have been developed to specifically target the enzyme COX-2, which is responsible for inflammation and pain, while sparing the enzyme COX-1, which helps protect the stomach lining [1][3]. As a result, these medications are less likely to cause stomach issues than aspirin and other traditional NSAIDs [3].

It is important to note that while newer NSAIDs may be easier on the stomach, they are not without risks. For example, COX-2 inhibitors have been associated with an increased risk of cardiovascular events, such as heart attack and stroke [2]. Therefore, it is essential to consult with a healthcare provider before taking any medication, including aspirin and other NSAIDs, to determine the best course of treatment based on individual health history and needs.

Sources:

1. DrugPatentWatch. (n.d.). Aspirin. Retrieved from <https://www.drugpatentwatch.com/p/tradename/ASPIRIN>
2. Singh, G. (2000). Recent considerations in nonsteroidal anti-inflammatory drug gastropathy. The American journal of medicine, 109(2), 115-121. Retrieved from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10145431/>
3. Yale Medicine. (2021). Acetaminophen vs. NSAIDs: Over-the-counter pain relievers. Retrieved from <https://www.yalemedicine.org/news/acetaminophen-nsaids-over-the-counter-pain-relievers>