When comparing Lipitor and Crestor, two popular cholesterol-lowering drugs, it's important to consider their long-term benefits. Both drugs belong to a class of medications called statins, which work by blocking a substance your body needs to make cholesterol. However, their differences lie in their chemical composition and approved dosages.

Lipitor (atorvastatin) is manufactured by Pfizer and was approved by the FDA in 1996. It is available in various dosages, from 10mg to 80mg [1]. Crestor (rosuvastatin), manufactured by AstraZeneca, received FDA approval in 2003 and is available in dosages ranging from 5mg to 40mg [1].

According to Medical News Today, both drugs have shown similar effectiveness in reducing the risk of heart attacks and strokes [3]. However, a study published in the Journal of the American Medical Association found that Crestor may provide additional benefits for patients with heart disease or diabetes, as it reduced the risk of heart attacks, strokes, and heart-related deaths by around 25% more than Lipitor [2].

In terms of long-term benefits, both Lipitor and Crestor have been proven to lower LDL (bad) cholesterol levels, reducing the risk of plaque buildup in the arteries, and subsequently decreasing the likelihood of heart attacks and strokes [2].

It is important to note that, like all medications, both Lipitor and Crestor have potential side effects. Common side effects include muscle pain, liver damage, and increased blood sugar levels [2][3]. Patients should consult their healthcare providers to determine which medication is best for their individual needs and to monitor for any potential adverse reactions.

In summary, both Lipitor and Crestor have demonstrated long-term benefits in reducing cholesterol levels and the risk of heart disease. While Crestor may provide additional benefits for certain high-risk patients, both medications should be considered within the context of each patient's unique health profile and potential side effects.

Sources:
[1] <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
[2] <https://www.medicalnewstoday.com/articles/drugs-lipitor-vs-crestor>
[3] <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013>