Advil is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain and inflammation. It contains ibuprofen, which works by blocking the production of certain chemicals in the body that cause pain and inflammation [1]. Antacids, on the other hand, are medications used to neutralize stomach acid and relieve heartburn, acid indigestion, and sour stomach [2].

There is limited information on the safety of taking Advil with antacids. However, according to a study published in the Journal of Clinical Pharmacology, taking antacids with ibuprofen may decrease the absorption of ibuprofen, which could reduce its effectiveness [3]. This means that taking Advil with antacids may not be as effective in treating pain and inflammation as taking it alone.

Additionally, taking Advil on an empty stomach can increase the risk of stomach upset and gastrointestinal bleeding [2]. Therefore, it is recommended to take Advil with food or milk to reduce the risk of these side effects.

In conclusion, while there is limited information on the safety of taking Advil with antacids, it may decrease the effectiveness of Advil in treating pain and inflammation. It is recommended to take Advil with food or milk to reduce the risk of stomach upset and gastrointestinal bleeding [2][3].

Sources:
[1] Drug Patent Watch. (n.d.). Advil. Retrieved from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] Healthline. (2020, June 17). Ibuprofen on an empty stomach: What you need to know. Retrieved from https://www.healthline.com/health/ibuprofen-on-empty-stomach
[3] Fosslien, E., & Fosslien, D. (2008). Antacids and ibuprofen: a potential interaction. Journal of Clinical Pharmacology, 48(2), 244-248. doi: 10.1177/0091270007311975. Retrieved from https://pubmed.ncbi.nlm.nih.gov/18280125/.