Based on the sources provided, there is limited information specifically addressing whether Advil can worsen depression symptoms. However, we can gather some insights from the available information.

Advil is a brand name for ibuprofen, which is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to relieve pain, reduce inflammation, and lower fever [1]. While Advil is generally considered safe when used as directed, it is important to note that all medications, including NSAIDs, can have potential side effects and interactions.

The first source provided, Drug Patent Watch, does not directly address the impact of Advil on depression symptoms. It primarily provides information on the patent status and expiration of the drug [1].

The second source, a study published on PubMed, investigates the effects of ibuprofen on the symptoms of depression in patients with major depressive disorder. The study found that ibuprofen had a modest antidepressant effect when used as an adjunct to standard antidepressant treatment. However, the study was limited to a specific group of patients and did not focus on Advil specifically [2].

The third source, a research article published on PMC, explores the potential role of NSAIDs, including ibuprofen, in the treatment of depression. The article suggests that there is some evidence to support the use of NSAIDs as adjunctive therapy for depression. However, it also acknowledges that more research is needed to fully understand the effectiveness and mechanisms of action [3].

Based on the available information, it is difficult to draw a definitive conclusion on whether Advil specifically worsens depression symptoms. However, it is important to note that individuals with depression may have unique responses to medications, and it is always recommended to consult with a healthcare professional before starting or changing any medication regimen.

In summary, while there is limited direct information on the impact of Advil on depression symptoms, some studies suggest that NSAIDs, including ibuprofen, may have potential benefits in the treatment of depression. However, further research is needed to fully understand the effects and mechanisms of action. It is always best to consult with a healthcare professional for personalized advice.

Sources:
[1] Drug Patent Watch. Advil. Retrieved from: https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] PubMed. Effects of ibuprofen on the symptoms of depression in patients with major depressive disorder: a randomized, double-blind, placebo-controlled study. Retrieved from: https://pubmed.ncbi.nlm.nih.gov/8707453/
[3] PMC. Non-steroidal anti-inflammatory drugs for the treatment of depression: A possible adjunctive treatment option? Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606303/