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How does age affect methotrexate dosage?

Age can have an impact on the dosage of methotrexate, a medication commonly used to treat various conditions such as cancer, rheumatoid arthritis, and psoriasis. The dosage of methotrexate is determined based on several factors, including the age of the patient.

According to the information provided in the sources, the dosage of methotrexate may vary depending on the age of the patient. In pediatric patients, the dosage is typically calculated based on body surface area (BSA) rather than age alone [1]. BSA takes into account the height and weight of the patient and is considered a more accurate measure for determining the appropriate dosage for children [1]. The dosage for pediatric patients is often lower compared to adults due to their smaller size and different metabolic rates [2].

For adults, the dosage of methotrexate is generally based on the specific condition being treated. In the case of cancer, higher doses of methotrexate may be required for certain types of tumors [3]. However, it is important to note that the dosage may also be influenced by other factors such as overall health, liver function, and the presence of any other medical conditions [2].

It is crucial for healthcare professionals to carefully consider the age and individual characteristics of each patient when determining the appropriate dosage of methotrexate. Close monitoring and regular blood tests are often necessary to ensure that the medication is effective and well-tolerated.

In summary, age can affect the dosage of methotrexate. Pediatric patients may receive lower doses based on their body surface area, while adults may receive varying doses depending on the specific condition being treated. Other factors such as overall health and liver function also play a role in determining the appropriate dosage.

[1] Drug Patent Watch. Methotrexate. Retrieved from
[2] National Center for Biotechnology Information. Methotrexate: Drug Information. Retrieved from
[3] PubMed. High-dose methotrexate in osteosarcoma. Retrieved from

Follow-up:   Does age impact the recommended methotrexate dosage? Are there specific methotrexate dosage adjustments based on age? How does age influence the optimal methotrexate dosage?

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