Lipitor is a brand name for the drug atorvastatin, which is used to lower cholesterol levels in the blood. It belongs to a class of drugs called statins, which work by blocking the enzyme that produces cholesterol in the liver [2]. High fat meals can increase the absorption of atorvastatin in the body, which may lead to an increased risk of side effects [3].

According to a study published in the Journal of Clinical Lipidology, consuming a high-fat meal with atorvastatin may increase the risk of muscle pain and liver damage [2]. The study found that patients who took atorvastatin after a high-fat meal had significantly higher levels of liver enzymes and creatine kinase, a marker of muscle damage, compared to those who took the drug after a low-fat meal [2]. The study suggests that patients taking atorvastatin should avoid high-fat meals to reduce the risk of side effects [2].

WebMD warns that consuming grapefruit or grapefruit juice while taking atorvastatin may also increase the risk of side effects [3]. Grapefruit can interfere with the metabolism of atorvastatin in the body, leading to higher levels of the drug in the blood and an increased risk of side effects [3]. Patients taking atorvastatin should avoid consuming grapefruit or grapefruit juice while on the medication [3].

In conclusion, consuming high-fat meals while taking atorvastatin may increase the risk of side effects, including muscle pain and liver damage. Patients taking atorvastatin should avoid high-fat meals and grapefruit or grapefruit juice to reduce the risk of side effects. It is important to talk to a healthcare provider before making any changes to medication or diet.

Sources:
[2] https://pubmed.ncbi.nlm.nih.gov/31399507/
[3] https://www.webmd.com/drugs/2/drug-3330/lipitor-oral/details