Advil is a nonsteroidal anti-inflammatory drug (NSAID) that is used to treat pain, fever, and inflammation. The active ingredient in Advil is ibuprofen. Ibuprofen works by blocking the production of prostaglandins, which are chemicals that cause pain and inflammation in the body [2].

Although Advil is generally considered safe when used as directed, there are potential long-term effects of daily Advil use. One of the most common side effects of Advil is gastrointestinal problems. Taking Advil regularly can irritate the lining of the stomach and intestines, which can lead to ulcers, bleeding, and other digestive issues [3].

In addition to gastrointestinal problems, long-term Advil use can also increase the risk of cardiovascular problems such as heart attack and stroke. This is because ibuprofen can increase blood pressure and interfere with blood clotting [2].

Another potential long-term effect of daily Advil use is kidney damage. Ibuprofen can reduce blood flow to the kidneys and cause kidney damage over time, especially in people who already have kidney problems [2].

It is important to note that the risk of these long-term effects increases with the duration and frequency of Advil use. Therefore, it is recommended to use Advil only as directed and for the shortest duration possible to minimize the risk of these side effects [3].

Sources:
[1] Drug Patent Watch. (n.d.). Advil. Retrieved from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] Alcohol and Drug Foundation. (2021, January 22). Ibuprofen. Retrieved from https://adf.org.au/drug-facts/ibuprofen/
[3] GoodRx. (n.d.). Advil Side Effects. Retrieved from https://www.goodrx.com/advil/advil-side-effects