Lipitor is a brand name for the drug atorvastatin, which is used to lower cholesterol levels in the blood. According to Drug Patent Watch [1], Lipitor is a type of statin drug that works by blocking an enzyme that the liver uses to produce cholesterol. Salt substitutes, on the other hand, are typically used by people who need to reduce their sodium intake.

There is limited information available on the potential interaction between Lipitor and salt substitutes. However, it is known that Lipitor can interact with certain medications, including lisinopril, which is a type of medication used to treat high blood pressure. According to Drugs.com [2], taking Lipitor and lisinopril together can increase the risk of developing muscle problems.

A study published in Circulation Research [3] found that high salt intake can reduce the effectiveness of statin drugs, including Lipitor. The study suggests that high salt intake can interfere with the way statins are metabolized in the liver, which can lead to higher levels of the drug in the bloodstream and an increased risk of side effects. However, the study did not specifically look at the interaction between Lipitor and salt substitutes.

In conclusion, there is limited information available on the potential interaction between Lipitor and salt substitutes. However, it is known that Lipitor can interact with certain medications, including lisinopril, which can increase the risk of developing muscle problems. Additionally, a study published in Circulation Research suggests that high salt intake can reduce the effectiveness of statin drugs, including Lipitor. It is important for individuals taking Lipitor to talk to their healthcare provider before using salt substitutes or making any significant changes to their diet.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.drugs.com/drug-interactions/lipitor-with-lisinopril-276-128-1476-0.html
[3] https://www.ahajournals.org/doi/full/10.1161/CIRCRESAHA.118.312782