Taking Lipitor and ibuprofen together can potentially affect liver function, as both medications have the potential to cause liver damage. Lipitor (atorvastatin) is a medication used to lower cholesterol levels, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation. According to the American Academy of Family Physicians [3], both medications can cause liver damage and should be used with caution in patients with liver disease.

Lipitor can cause liver enzyme abnormalities, and in rare cases, it can lead to liver failure. The risk of liver damage is higher in patients who take higher doses of Lipitor or who have pre-existing liver disease [1]. Similarly, ibuprofen can cause liver enzyme abnormalities and can lead to liver damage in rare cases. The risk of liver damage is higher in patients who take higher doses of ibuprofen or who have pre-existing liver disease [3].

It is important to note that the risk of liver damage from taking Lipitor and ibuprofen together may be higher than taking either medication alone. According to a report by NBC News [2], Pfizer's COVID-19 pills, which contain a combination of atorvastatin (the active ingredient in Lipitor) and a protease inhibitor, have been found to potentially cause liver damage in some patients. The report suggests that the combination of atorvastatin and the protease inhibitor may increase the risk of liver damage.

In conclusion, taking Lipitor and ibuprofen together can potentially affect liver function, as both medications have the potential to cause liver damage. Patients who take these medications together should be monitored closely for signs of liver damage, especially if they have pre-existing liver disease or are taking higher doses of the medications. It is important to consult with a healthcare provider before taking any new medications or combinations of medications.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.nbcnews.com/health/health-news/pfizer-covid-pills-covid-symptoms-may-risky-drugs-rcna9683
[3] https://www.aafp.org/pubs/afp/issues/2007/0801/p391.html