Vascepa is a prescription medication that contains the active ingredient icosapent ethyl, which is used to lower high levels of triglycerides in the blood. Antidepressants are a class of medications used to treat depression, anxiety, and other mental health disorders. When taken together, there is a potential for drug interactions and side effects.

According to the Drug Patent Watch website [1], there are no known drug interactions between Vascepa and antidepressants. However, it is important to note that this does not mean that there are no potential side effects or risks associated with taking these medications together.

The SingleCare website [2] lists some common side effects of Vascepa, including joint pain, muscle pain, and stomach upset. These side effects may be more likely to occur if Vascepa is taken with certain antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs). These medications can also cause similar side effects, which may be more severe when taken together.

A study published in the Journal of Clinical Psychopharmacology [3] found that there were no significant interactions between icosapent ethyl (the active ingredient in Vascepa) and the antidepressant venlafaxine. However, the study also noted that more research is needed to determine the potential interactions between Vascepa and other antidepressants.

In conclusion, while there are no known drug interactions between Vascepa and antidepressants, there is a potential for side effects and risks when taking these medications together. It is important to talk to your healthcare provider about any medications you are taking and any potential interactions or side effects.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] https://www.singlecare.com/blog/vascepa-side-effects/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628733/