Advil is a brand name for ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. According to Drug Patent Watch [1], Advil's active ingredient, ibuprofen, has no known interactions with antidepressants. However, it is important to note that the combination of Advil and antidepressants can cause adverse effects on the stomach, kidneys, and liver.

Antidepressants are a class of drugs used to treat depression and other mental health conditions. The Mayo Clinic [3] explains that combining antidepressants with other medications can cause adverse effects, including increased risk of bleeding, serotonin syndrome, and changes in blood pressure.

A study published in the National Center for Biotechnology Information [2] found that NSAIDs like Advil can reduce the effectiveness of selective serotonin reuptake inhibitors (SSRIs), a type of antidepressant. The study also suggests that NSAIDs can increase the risk of gastrointestinal bleeding when taken with SSRIs.

In conclusion, while Advil's active ingredient, ibuprofen, has no known interactions with antidepressants [1], combining Advil and antidepressants can cause adverse effects on the stomach, kidneys, and liver. Moreover, a study suggests that NSAIDs like Advil can reduce the effectiveness of SSRIs and increase the risk of gastrointestinal bleeding when taken with SSRIs [2]. Therefore, it is essential to consult with a healthcare provider before combining Advil and antidepressants.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884264/
[3] https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20044970