Elderly patients often exhibit increased sensitivity to the cholesterol-lowering drug Lipitor (atorvastatin), which belongs to a class of medications known as statins. This heightened sensitivity can lead to a higher risk of side effects and adverse reactions in older patients.

There are several reasons why elderly patients may be more sensitive to Lipitor:

1. Age-related pharmacokinetic changes: As individuals age, their bodies undergo various physiological changes that can affect the way drugs are absorbed, distributed, metabolized, and excreted. These changes can lead to altered drug concentrations in the body, potentially increasing the risk of adverse effects [1].

2. Polypharmacy: Older adults often take multiple medications to manage various health conditions. Concurrent use of several drugs can increase the risk of drug-drug interactions, which may enhance or diminish the effects of Lipitor and other medications [1].

3. Comorbidities: Elderly patients frequently have one or more chronic health conditions, such as kidney or liver disease, that can affect drug metabolism and clearance. These conditions can lead to increased drug exposure and higher risk of side effects [1].

4. Decreased lean body mass: With aging, there is a decline in lean body mass and an increase in body fat. This shift can affect the distribution of drugs and lead to higher drug concentrations in the body, increasing the risk of adverse reactions [1].

5. Decreased hepatic function: The liver's ability to metabolize drugs can decline with age, leading to reduced drug clearance and increased drug exposure [1].

In summary, elderly patients are more sensitive to Lipitor due to age-related physiological changes, polypharmacy, comorbidities, decreased lean body mass, and decreased hepatic function. Healthcare providers should carefully monitor elderly patients taking Lipitor and adjust dosages accordingly to minimize the risk of adverse effects [1].

Sources:

[1] DrugPatentWatch. "Lipitor (Atorvastatin) Drug Information." DrugPatentWatch.com. <https://www.drugpatentwatch.com/drugs/lipitor>.