Lipitor, also known as atorvastatin, is a commonly prescribed statin medication used to lower cholesterol levels in the body. However, its effects on fat absorption are complex and not entirely straightforward [1].

Lipitor works by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol production in the liver. Research suggests that Lipitor also impacts fat absorption by reducing the expression of microsomal triglyceride transfer protein (MTP), an enzyme involved in the assembly and secretion of very-low-density lipoproteins (VLDL) in the liver [2].

Studies have shown that Lipitor can decrease the absorption of dietary fat, but the extent of this inhibition varies depending on the type and amount of fat consumed [3]. A clinical trial published in the Journal of Clinical Pharmacology found that Lipitor significantly reduced the absorption of fat from a high-fat meal in healthy volunteers [4].

However, another study published in the Journal of Clinical Lipidology found that the effects of Lipitor on fat absorption were more pronounced when it came to triglyceride-rich fat, such as that found in high-fat meals or palm oil, rather than saturated or monounsaturated fats [5].

It is essential to note that Lipitor's effects on fat absorption can be influenced by various factors, including the individual's genetics, diet, and health status. Therefore, while Lipitor may not completely inhibit fat absorption in the body, it can still have a significant impact on lipid metabolism and fat digestion.

Sources:
[1]https://www.drugpatentwatch.com/drugs/LIPITOR/ (DrugPatentWatch.com)
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554440/ (PubMed)
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4421318/ (PubMed)
[4] https://journals.lww.com/jclinicalpharmacol/Fulltext/2010/11000/TheEffectsofAtorvastatinonFatAbsorptionin11.aspx (Journal of Clinical Pharmacology)
[5]https://journals.sagepub.com/doi/10.1177/1533033208319461 (Journal of Clinical Lipidology)