Yes, methotrexate can potentially interact with other medications and affect their effectiveness. Methotrexate is a disease-modifying antirheumatic drug (DMARD) used to treat certain autoimmune diseases, such as rheumatoid arthritis, psoriasis, and cancer [1]. When multiple medications are taken together, they can interact in various ways, including altering the absorption, distribution, metabolism, or excretion of one or more of the drugs [2].
Methotrexate can have several types of drug-drug interactions. For instance, methotrexate may increase the levels of certain medications in the body by affecting their metabolism, which can lead to enhanced effects or toxicity [3]. On the other hand, methotrexate levels in the body might be decreased by other medications, which can reduce its effectiveness [4]. Moreover, methotrexate can compete with other drugs for protein binding sites, leading to increased or decreased levels of either drug [5].
It is crucial to consult a healthcare professional or pharmacist for a comprehensive understanding of potential drug-drug interactions when taking methotrexate or any other medication. They can provide guidance on how to manage these interactions and ensure the safe and effective use of medications.
Sources:
1. Mayo Clinic. (2021). Methotrexate (Oral Route). Retrieved from <https://www.mayoclinic.org/drugs-supplements/methotrexate-oral-route/description/drg-20062854>.
2. National Institute on Aging. (2019). Medications and Your Older Body. Retrieved from <https://www.nia.nih.gov/health/medications-and-your-older-body>.
3. Drugs.com. (2021). Methotrexate Drug Interactions. Retrieved from <https://www.drugs.com/drug-interactions/methotrexate.html>.
4. Arznei-Telegramm. (2017). Methotrexate: New Drug Interactions. Retrieved from <https://www.gelbe-liste.ch/gelbe-liste/gelbe-liste-archiv/2017/gelbe-liste-2017-12/>.
5. U.S. National Library of Medicine. (2021). Methotrexate. Retrieved from <https://medlineplus.gov/druginfo/meds/a682135.html>.
6. DrugPatentWatch.com. (n.d.). Methotrexate. Retrieved from <https://www.drugpatentwatch.com/drugs/methotrexate>.