Lipitor is a brand name for the drug atorvastatin, which is a type of medication called a statin that is used to lower cholesterol levels in the blood [1]. While there is no direct evidence that Lipitor affects alcohol tolerance when drinking wine, it is generally recommended to limit alcohol consumption while taking statins, including Lipitor [2][3].

According to Medical News Today, alcohol can interfere with the liver's ability to process statins, which can increase the risk of liver damage and other side effects [2]. Furthermore, excessive alcohol consumption can also raise cholesterol levels, which can counteract the benefits of taking Lipitor [2].

Harvard Health Publishing also notes that alcohol can increase the risk of muscle damage and liver problems when taken with statins [3]. However, moderate alcohol consumption (defined as up to one drink per day for women and up to two drinks per day for men) is generally considered safe for people taking statins [3].

In summary, while there is no direct evidence that Lipitor affects alcohol tolerance when drinking wine, it is generally recommended to limit alcohol consumption while taking statins, including Lipitor. Excessive alcohol consumption can increase the risk of liver damage and other side effects, while moderate alcohol consumption is generally considered safe for people taking statins [2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.medicalnewstoday.com/articles/statins-and-alcohol
[3] https://www.health.harvard.edu/newsletter_article/do-alcohol-and-statins-mix