Ezetimibe and Vascepa are both used to treat high cholesterol levels in the body. Ezetimibe works by reducing the amount of cholesterol absorbed by the body, while Vascepa works by reducing the levels of triglycerides, a type of fat, in the body. According to the sources provided, there is no evidence to suggest that taking ezetimibe with Vascepa is unsafe in the long term.

The first source [1] provides information about ezetimibe and its patent status. It does not provide any information about the safety of taking ezetimibe with Vascepa.

The second source [2] is a study that compares the effects of Vascepa and ezetimibe on lipid levels in patients with high cholesterol. The study found that both drugs were effective in reducing lipid levels and were well-tolerated by patients. However, this study does not provide information about the safety of taking the two drugs together in the long term.

The third source [3] is a clinical resource that provides information about the management of hypertriglyceridemia in adults. It states that combining ezetimibe with a statin, another type of cholesterol-lowering drug, has been shown to be safe and effective in reducing lipid levels. However, this source does not specifically address the safety of taking ezetimibe with Vascepa.

In summary, while there is no direct evidence to suggest that taking ezetimibe with Vascepa is unsafe in the long term, more research may be needed to fully understand the potential risks and benefits of combining these two drugs. Patients should always consult with their healthcare provider before starting any new medication or making changes to their current treatment plan.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/EZETIMIBE
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671468/
[3] https://www.uptodate.com/contents/hypertriglyceridemia-in-adults-management