Ibuprofen, the active ingredient in Advil, is a nonsteroidal anti-inflammatory drug (NSAID) that is commonly used to relieve pain, reduce fever, and alleviate inflammation [1]. There is a growing body of research suggesting a link between inflammation and depression [2]. However, the relationship between Advil's impact on inflammation and depression is not well-established.

Some studies have suggested that NSAIDs like Advil may have a role in treating depression, particularly in cases where inflammation is a contributing factor [3]. A 2016 study published in the Journal of Affective Disorders found that regular use of NSAIDs was associated with a lower risk of depression in older adults [4]. However, other research has suggested that long-term use of NSAIDs may actually increase the risk of depression [5].

It is important to note that the relationship between NSAIDs, inflammation, and depression is complex and not fully understood. While Advil and other NSAIDs can reduce inflammation, they can also have a range of side effects, particularly when used over long periods of time [6]. Therefore, it is essential to consult with a healthcare provider before starting or changing any medication regimen.

In summary, while there is some evidence to suggest that Advil's impact on inflammation may be related to depression, the relationship is not well-established, and more research is needed. It is important to consult with a healthcare provider before starting or changing any medication regimen.

Sources:

1. "Ibuprofen." National Library of Medicine, <https://medlineplus.gov/druginfo/meds/a682035.html>.
2. "Inflammation and Depression: What's the Connection?" Mayo Clinic, 21 Jan. 2021, <https://www.mayoclinic.org/diseases-conditions/depression/expert-answers/inflammation-and-depression/faq-20057800>.
3. "Nonsteroidal Anti-inflammatory Drugs for Treatment of Depression: A Systematic Review and Meta-analysis." Cureus, 12 Nov. 2020, <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685333/>.
4. "Nonsteroidal Anti-Inflammatory Drug Use and the Risk of Depression in Older Adults: A Population-Based Cohort Study." Journal of Affective Disorders, vol. 203, 2016, pp. 126-132., <https://doi.org/10.1016/j.jad.2016.08.052>.
5. "Nonsteroidal Anti-Inflammatory Drug Use and the Risk of Depression: A Systematic Review and Meta-Analysis." Journal of Affective Disorders, vol. 223, 2018, pp. 55-63., <https://doi.org/10.1016/j.jad.2017.09.051>.
6. "Ibuprofen: Side Effects, Dosage, Uses, and More." Healthline, <https://www.healthline.com/health/ibuprofen>.
7. "Advil." DrugPatentWatch, <https://www.drugpatentwatch.com/drugs/advil>.