Lipitor is a medication used to lower cholesterol levels in the body. According to the information provided by Drug Patent Watch [1], Lipitor should be taken with or without food, as food does not affect its absorption. However, it is important to note that high-fat meals may decrease the effectiveness of the medication.

A study published in the Journal of Clinical Lipidology [2] found that taking Lipitor with a low-fat meal was just as effective as taking it with a high-fat meal. The study concluded that the effectiveness of Lipitor was not affected by the type of meal it was taken with.

Another study published in the Journal of Cardiovascular Pharmacology and Therapeutics [3] found that taking Lipitor with a low-fat meal was more effective than taking it with a high-fat meal. The study concluded that taking Lipitor with a low-fat meal could potentially increase its effectiveness in reducing cholesterol levels.

In summary, Lipitor can be taken with or without food, but high-fat meals may decrease its effectiveness. Taking Lipitor with a low-fat meal may be just as effective or even more effective than taking it with a high-fat meal. It is important to consult with a healthcare provider regarding the best way to take Lipitor.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://pubmed.ncbi.nlm.nih.gov/21269482/
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766553/