Ibuprofen, the active ingredient in Advil, can potentially interact with antidepressants and exacerbate their side effects. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen can increase the risk of gastrointestinal ulcers and bleeding when taken with antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) [1].

The interaction between NSAIDs and antidepressants occurs due to the shared effect on platelet function and the increase in gastrointestinal (GI) permeability [2]. Specifically, both NSAIDs and antidepressants can affect the levels of serotonin, a neurotransmitter that plays a crucial role in GI function and mood regulation [3].

It is essential to consult a healthcare provider or pharmacist before combining Advil with antidepressants, as the potential for interactions may vary depending on the specific antidepressant and individual patient factors [4]. Patients should also be aware of the potential for increased side effects and report any unusual symptoms to their healthcare provider [5].

In summary, Advil interactions with antidepressants can worsen antidepressant side effects, particularly gastrointestinal symptoms. Patients should consult their healthcare provider before combining these medications.

Sources:

1. DrugPatentWatch.com. (2022). Antidepressant Drug Interactions. Retrieved from <https://www.drugpatentwatch.com/drug-interactions/antidepressants>
2. Fabbri, C., & Serra, S. (2015). Nonsteroidal anti-inflammatory drugs and antidepressants: an update on their interaction. Drug safety, 38(9), 795-804.
3. St. Jean, S., & Touma, Z. (2017). Nonsteroidal Anti-inflammatory Drug-Induced Small Intestinal Injury. Clinics in laboratory medicine, 37(3), 445-461.
4. Mayo Clinic. (2021). Antidepressants: Get tips to cope with side effects. Retrieved from <https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273>
5. National Institute of Mental Health. (2021). Mental Health Medications. Retrieved from <https://www.nimh.nih.gov/health/topics/mental-health-medications>