After reviewing the available information, it is generally recommended to take Lipitor, a medication used to treat high cholesterol, with a meal. According to the drug's official website, Lipitor can be taken at any time of the day but should be taken consistently with or without food [1]. However, some people may find that taking Lipitor with food helps to reduce stomach upset [2].

It is important to note that Lipitor should not be taken with grapefruit juice, as this can increase the levels of the drug in the body and lead to adverse effects [1].

Additionally, it is always recommended to consult with a healthcare professional or pharmacist for personalized advice on taking medications, including Lipitor. They can provide guidance based on an individual's specific medical history and current medications [3].

In summary, while Lipitor can be taken with or without food, taking it with a meal may help to reduce stomach upset. It is important to avoid taking Lipitor with grapefruit juice. As with any medication, it is recommended to consult with a healthcare professional for personalized advice.

Sources:

* [1] <https://www.lipitor.com/consumers/taking-lipitor/dosing-and-administration.aspx>
* [2] <https://www.drugs.com/lipitor.html>
* [3] <https://www.drugpatentwatch.com/drugs/lipitor>