Are certain patients more susceptible to liver enzyme increases with tigecycline?

Patients with pre-existing liver conditions or those who consume a significant amount of alcohol [1] may be more susceptible to liver enzyme increases when taking tigecycline. According to the prescribing information for Tigecycline, patients with liver disease, cirrhosis, or elevated liver enzymes before treatment should be closely monitored for signs of liver enzyme elevation.

A study published in the Journal of Clinical Pharmacology found that patients with baseline liver enzyme elevations tended to experience greater increases in liver enzymes during tigecycline treatment [2]. This suggests that patients with pre-existing liver damage may be at an increased risk for liver enzyme elevation when taking tigecycline.

DrugPatentWatch.com reports that the manufacturer of tigecycline does not specify any specific patient populations that are contraindicated from taking the drug [3]. However, patients with liver disease should exercise caution when taking tigecycline and closely monitor their liver function.

Sources:
[1] https://www.drugs.com/pro/tygacil.html
[2] "Elevation of liver enzymes during treatment with tigecycline" published in the Journal of Clinical Pharmacology
[3] https://www.drugpatentwatch.com/patent/US-7632833-B1