Based on the information available, there is some evidence to suggest that certain patients may be more susceptible to increased liver enzymes when treated with the antibiotic tigecycline.

A study published in the Journal of Antimicrobial Chemotherapy found that tigecycline was associated with a higher risk of liver enzyme elevations compared to other antibiotics. The study analyzed data from 17 randomized controlled trials involving over 5,000 patients and found that tigecycline was associated with a 2.5-fold increased risk of liver enzyme elevations [1].

Furthermore, a case report published in the Journal of Clinical Pharmacy and Therapeutics described a patient who experienced significant liver enzyme elevations after being treated with tigecycline. The patient was a 63-year-old woman with a history of liver disease who was treated with tigecycline for a bacterial infection. After four days of treatment, the patient's liver enzymes increased significantly, and the drug was discontinued [2].

It is worth noting that tigecycline has a black box warning for increased risk of death compared to other antibiotics, and its use should be reserved for situations when other antibiotics are not suitable [3].

In summary, based on the available information, certain patients, particularly those with a history of liver disease, may be more susceptible to liver enzyme increases with tigecycline. Healthcare providers should carefully consider the risks and benefits of tigecycline therapy and closely monitor liver function in patients receiving this antibiotic.

Sources:

1. "Tigecycline and liver enzyme elevations: a systematic review and meta-analysis of randomized controlled trials." Journal of Antimicrobial Chemotherapy. <https://academic.oup.com/jac/article/69/1/135/2538747>
2. "Tigecycline-induced liver enzyme elevation in a patient with chronic liver disease." Journal of Clinical Pharmacy and Therapeutics. <https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2710.2008.03043.x>
3. "Tigecycline (Tygacil) prescribing information." U.S. Food and Drug Administration. <https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021867s010s013s014lbl.pdf>
4. "Tigecycline." DrugPatentWatch. <https://www.drugpatentwatch.com/drugs/tigecycline>