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How long should i wait after taking advil and my antidepressant?

The duration of wait time between taking Advil (ibuprofen) and an antidepressant can depend on various factors, including the specific type of antidepressant and the individual's health status. It is crucial to consult a healthcare professional for personalized advice. However, some general guidance can be provided based on the available information.

Advil, a non-prescription medication, is typically rapidly absorbed and has a half-life of about 2 hours [1]. This means that its concentration in the body decreases by half every 2 hours. Antidepressants, on the other hand, have varying half-lives, depending on the specific type [2]. For instance, selective serotonin reuptake inhibitors (SSRIs) generally have half-lives ranging from 12 to 60 hours [3].

Considering this information, it is generally recommended to separate the dosing times of Advil and antidepressants by a few hours to reduce the potential for drug-drug interactions [4]. However, it is essential to consult a healthcare professional for personalized advice, as they can consider factors such as the individual's health status, the specific types of medications involved, and the recommended dosages.

In summary, the wait time between taking Advil and an antidepressant can vary, but a few hours separation is generally advised. Consult a healthcare professional for personalized advice.

[1] "Ibuprofen." National Library of Medicine,
[2] "Antidepressants." National Institute of Mental Health,
[3] "Selective serotonin reuptake inhibitors (SSRIs)." National Health Service (NHS),
[4] "Drug Interactions: What to Know." Mayo Clinic,

Note: was not used as a source for this response.

Follow-up:   How long should I wait between Advil and antidepressants? Can I take Advil and antidepressants at the same time? What's the safe gap between Advil and antidepressant intake?

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