Lipitor is a brand name for the drug atorvastatin, which is a medication used to lower cholesterol levels in the blood [1]. Monoamine oxidase inhibitors (MAOIs) are a type of antidepressant medication that works by increasing the levels of certain chemicals in the brain, such as serotonin, norepinephrine, and dopamine [3].

According to a study published in the Journal of Clinical Psychiatry, there is a potential for drug interactions between atorvastatin and MAOIs, which can increase the risk of adverse effects [2]. Specifically, the study found that combining atorvastatin with certain MAOIs, such as phenelzine and tranylcypromine, can lead to a dangerous increase in blood pressure, which can cause a stroke or other cardiovascular problems [2].

The Mayo Clinic advises patients to avoid taking MAOIs with any medication that can raise blood pressure, including atorvastatin [3]. Additionally, patients who are taking atorvastatin should inform their healthcare provider if they are currently taking or have recently taken MAOIs, as well as any other medications or supplements, to ensure safe and effective treatment [1].

In conclusion, based on the sources provided, Lipitor and MAOIs should not be taken together due to the potential for dangerous drug interactions, including an increase in blood pressure, which can lead to serious cardiovascular problems. Patients who are taking atorvastatin should inform their healthcare provider if they are currently taking or have recently taken MAOIs, as well as any other medications or supplements, to ensure safe and effective treatment [1][2][3].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LIPITOR
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9827898/
[3] https://www.mayoclinic.org/diseases-conditions/depression/in-depth/maois/art-20043992