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How does aspirin affect clotting factors?



Aspirin is a medication that is commonly used as an anti-inflammatory and pain reliever. It is also known to affect clotting factors in the body. Aspirin works by inhibiting the production of prostaglandins, which are chemicals that promote inflammation and blood clotting [1].

According to a study published in the American Heart Association's journal, aspirin irreversibly inhibits the enzyme cyclooxygenase (COX), which is responsible for the production of thromboxane A2 (TXA2) [3]. TXA2 is a potent vasoconstrictor and platelet aggregator, which means it promotes the formation of blood clots. By inhibiting the production of TXA2, aspirin reduces the ability of platelets to stick together and form clots [3].

Another study published in the National Center for Biotechnology Information found that aspirin also inhibits the production of other prostaglandins, including prostacyclin (PGI2) [2]. PGI2 is a vasodilator and inhibitor of platelet aggregation. By inhibiting the production of PGI2, aspirin reduces the ability of blood vessels to dilate and platelets to be inhibited, which can lead to an increased risk of blood clots [2].

In summary, aspirin affects clotting factors in the body by inhibiting the production of prostaglandins, including TXA2 and PGI2. By inhibiting these chemicals, aspirin reduces the ability of platelets to stick together and form clots, as well as the ability of blood vessels to dilate and platelets to be inhibited.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ASPIRIN
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852201/
[3] https://www.ahajournals.org/doi/full/10.1161/ATVBAHA.109.183707



Follow-up:   What other medications interact with aspirin? Can aspirin reduce the risk of heart attack? How long does aspirin affect clotting factors?





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