Advil is a nonsteroidal anti-inflammatory drug (NSAID) that contains ibuprofen as its active ingredient [1]. It works by blocking the production of prostaglandins, which are chemicals that cause inflammation, pain, and fever in the body. However, prostaglandins also play a protective role in the stomach lining by promoting the secretion of mucus and bicarbonate, which help to neutralize stomach acid and prevent damage to the stomach wall [2].
When Advil is taken for a prolonged period or in high doses, it can interfere with the production of prostaglandins, which can lead to a decrease in the protective factors of the stomach lining. This can cause irritation, inflammation, and erosion of the stomach lining, leading to the development of stomach ulcers [3]. The risk of stomach ulcers is further increased in people who have a history of ulcers, are over 60 years old, consume alcohol regularly, or take other medications that can irritate the stomach lining [2].
It is important to note that not everyone who takes Advil will develop stomach ulcers, and the risk can be minimized by taking the medication as directed, avoiding alcohol, and consulting a healthcare provider before taking Advil with other medications [3]. If symptoms such as stomach pain, nausea, or vomiting occur while taking Advil, it is important to seek medical attention immediately to prevent further complications [2].
In conclusion, Advil can cause stomach ulcers by interfering with the production of protective prostaglandins in the stomach lining. The risk of stomach ulcers can be minimized by taking the medication as directed and consulting a healthcare provider before taking Advil with other medications. If symptoms occur, medical attention should be sought immediately.
Sources:
[1] DrugPatentWatch. (n.d.). Advil. Retrieved from https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] National Center for Biotechnology Information. (2017). Ibuprofen. In StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK310269/
[3] GoodRx. (2021). Ibuprofen: Stomach Ulcers and Advil/Motrin. Retrieved from https://www.goodrx.com/ibuprofen/ibuprofen-stomach-ulcers-advil-motrin