Advil (ibuprofen) and aspirin are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to relieve pain and reduce fever. They work by blocking the production of prostaglandins, which are responsible for inflammation and pain. However, taking both medications together can increase the risk of side effects, such as stomach ulcers, bleeding, and kidney damage [2].

According to the FDA, taking aspirin and ibuprofen together may decrease the effectiveness of aspirin in preventing heart attacks and strokes. Aspirin is often prescribed in low doses to reduce the risk of blood clots, which can lead to heart attacks and strokes. Ibuprofen can interfere with the antiplatelet effect of aspirin, which means that aspirin may not work as well to prevent blood clots [2].

Therefore, it is generally not recommended to take Advil (ibuprofen) and aspirin together unless under the guidance of a healthcare provider. If you need to take both medications, your healthcare provider may recommend taking them at different times or adjusting the dosage [2].

In conclusion, Advil and aspirin are both NSAIDs that can be used to relieve pain and reduce fever. However, taking them together can increase the risk of side effects and decrease the effectiveness of aspirin in preventing heart attacks and strokes. It is important to consult with a healthcare provider before taking both medications together [2].

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/ADVIL
[2] https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/information-about-taking-ibuprofen-and-aspirin-together
[3] https://www.healthline.com/health/pain-relief/aspirin-ibuprofen