After analyzing the sources provided, there is no evidence to suggest that Vascepa affects the efficacy of antidepressants. Vascepa is a prescription medication used to treat high triglyceride levels in the blood [1]. The drug contains the active ingredient icosapent ethyl, which is a type of omega-3 fatty acid [2].

Antidepressants are medications used to treat depression, anxiety, and other mood disorders. They work by altering the levels of certain chemicals in the brain, such as serotonin and dopamine [3].

According to a study published in the Journal of Clinical Psychopharmacology, omega-3 fatty acids may have some antidepressant effects, but more research is needed to confirm this [2]. However, the study did not investigate the potential interaction between Vascepa and antidepressants.

Furthermore, the patient tips for Vascepa on Drugs.com do not mention any interactions with antidepressants [4].

In conclusion, based on the sources provided, there is no evidence to suggest that Vascepa affects the efficacy of antidepressants. However, it is always important to consult with a healthcare professional before starting any new medication or changing your current medication regimen.

Sources:
[1] DrugPatentWatch. Vascepa. Retrieved from https://www.drugpatentwatch.com/p/tradename/VASCEPA
[2] Mischoulon, D., & Freeman, M. P. (2013). Omega-3 fatty acids in psychiatry. The Journal of Clinical Psychiatry, 74(3), 263-264. doi: 10.4088/JCP.13f08522
[3] Mayo Clinic. Antidepressants: Selecting one that's right for you. Retrieved from https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20046273
[4] Drugs.com. Vascepa patient tips. Retrieved from https://www.drugs.com/tips/vascepa-patient-tips